beta-Mangostin , 98+% , 20931-37-7
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB686.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 175-176℃ |
| Boiling point: | 616.5±55.0 °C(Predicted) |
| Density | 1.212 |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| pka | 7.05±0.20(Predicted) |
| color | Yellow |
| Stability: | Light Sensitive |
Description and Uses
β-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites. It inhibits growth of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA; MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively), P. falciparum (IC50 = 3 μg/ml), and M. tuberculosis (MIC = 6.25 μg/ml). β-Mangostin inhibits fatty acid synthase (FASN) with an IC50 value of 24.83 μM. It induces cell cycle arrest at the G2/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells. β-Mangostin also inhibits LPS-induced nitric oxide and prostaglandin E2 (PGE2; ) production in RAW264.7 cells and reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis.
β-Mangostin is isolated from the stem bark of Garcinia mangostana L. which shows significant cytotoxicities and anti-inflammatory activities against the LPS-induced RAW cell 264.7. Also, it demonstrates anti-metastatic activity against human hepatocellular carcinoma (HCC) cells, which may act as a promising therapeutic agent for the treatment of HCC.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H227 |
| Precautionary statements | P501-P210-P280-P370+P378-P403+P235 |
