(S)-4-Methyloxazolidine-2,5-dione , 95% , 2224-52-4

CAS NO.：2224-52-4

Empirical Formula: C4H5NO3

Molecular Weight: 115.09

MDL number: MFCD03411276

EINECS: 218-750-4

PRODUCT Properties

• Melting point: 92℃
• alpha: +5.13°(25/D,c=6.4,dioxane)
• Density: 1.296
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: DMSO (Very Slightly, Heated)
• form: Solid
• pka: 9.38±0.40(Predicted)
• color: White to Off-White
• InChI: InChI=1S/C4H5NO3/c1-2-3(6)8-4(7)5-2/h2H,1H3,(H,5,7)/t2-/m0/s1
• InChIKey: DTETYCNJKAUROO-REOHCLBHSA-N
• SMILES: O1C(=O)[C@H](C)NC1=O

Description and Uses

(S)-4-Methyl-2,5-oxazolidonedione is also known as N-Carboxy anhydrides. The Fuchs-Farthing method, reported in 1922, was the only practical method for preparing (S)-4-Methyl-2,5-oxazolidonedione[1]. N-Carboxy anhydrides (NCAs) are important as α-amino acid building blocks for the synthesis of oligopeptides and nonpeptide compounds, and for the synthesis of polypeptides[2]. The polymerization of NCAs is the main process for the preparation of polypeptides, and its purity and side chains can significantly affect the synthesized polypeptides. NCAs polymerizations have been initiated using many different nucleophiles and bases, the most common being primary amines and alkoxide anions[3].

(S)-4-Methyl-2,5-oxazolidonedione is composed of oxazolidine ring and 2,5-dione ring. It exhibits chirality, meaning it exists as two non-superimposable mirror image forms. Therefore, it can be used as an organic reagent for the synthesis of enantiomeric pure substances. (S)-4-Methyl-2,5-oxazolidonedione is a reagent used in the synthesis of poly(γ-benzyl-L-glutamate) and its block polypeptides with alanine, leucine and phenylalanine.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P261-P280-P305+P351+P338
• HS Code: 2934999090