Tetrahydrouridine , 98% , 18771-50-1
Synonym(s):
InSolution Tetrahydrouridine - CAS 18771-50-1 - Calbiochem;Tetrahydrouridine - CAS 18771-50-1 - Calbiochem;THU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB392.00 | In Stock |
|
| 5mg | RMB882.40 | In Stock |
|
| 10mg | RMB1324.00 | In Stock |
|
| 25mg | RMB2251.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >195°C (dec.) |
| Boiling point: | 668.6±55.0 °C(Predicted) |
| Density | 1.622±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 12.50±0.40(Predicted) |
| color | White to Off-White |
| Stability: | Light Sensitive |
Description and Uses
Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively). Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2’-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.
3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
