SuraminSodium , 98% , 129-46-4
Synonym(s):
P2Y Antagonist I, Purinergic Receptor P2Y Antagonist I, PTP Inhibitor VI;PTP Inhibitor VI, Purinergic Receptor P2Y Antagonist I, P2Y Antagonist I;Suramin, Sodium Salt - CAS 129-46-4 - Calbiochem;Suramine sodium salt
CAS NO.：129-46-4
Empirical Formula: C51H34N6Na6O23S6
Molecular Weight: 1429.17
MDL number: MFCD00210217
EINECS: 204-949-3
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB632.80 | In Stock |
|
| 50mg | RMB948.80 | In Stock |
|
| 100mg | RMB1422.40 | In Stock |
|
| 250mg | RMB2132.80 | In Stock |
|
| 1g | RMB5891.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >260°C (dec.) |
| storage temp. | 0-6°C |
| solubility | H2O: >10mg/mL |
| form | Crystalline Powder |
| color | White |
| PH | pH(10g/l, 25℃) : 5.0～8.0 |
| Water Solubility | soluble |
| BRN | 3694087 |
| Stability: | Hygroscopic |
| InChIKey | VAPNKLKDKUDFHK-UHFFFAOYSA-H |
Description and Uses
Introduced into therapy for the treatment of early trypanosomiasis in the 1920s, suramin, a bis-hexasulfonatednaphthylurea, is still considered to be the drug of choice for treatment of non-CNS-associated African trypanosomiasis.
Suramin sodium is a compound with a dyelike structure. Suramin is most effective against T. b. rhodesiense, but has also been used against T. b. gambiense infection. The compound causes side effects such as nausea, photophobia, and peripheral neuropathy which disappear shortly after conclusion of administration. Because the drug is unable to pass the bloodbrain barrier, prompt treatment of patients is essential. Suramin in combination with tryparsamide is an alternative that has been investigated.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | QM7000000 |
| F | 3-10 |
| HS Code | 29242998 |
| Toxicity | LD50 in mice (mg/kg): ~620 i.v. (Hawking) |
