Boc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid , 95% , 882847-13-4

Synonym(s):
Boc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid;Boc-NH-(PEG)₅-COOH (22 atoms)

CAS NO.：882847-13-4

Empirical Formula: C20H39NO10

Molecular Weight: 453.52

MDL number: MFCD07781255

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: Soluble in DMSO
• form: clear liquid
• color: Colorless to Light yellow to Light orange

Description and Uses

t-Boc-N-amido-PEG6-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Safety

• WGK Germany: 3
• HS Code: 29225090