![(2R,3R,4S,5R)-2-(5,6-Dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol](https://img.chemicalbook.com/CAS/GIF/53-85-0.gif)
BD0160553
(2R,3R,4S,5R)-2-(5,6-Dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol , 98% , 53-85-0
Synonym(s):
5,6-Dichloro-1-β-D -ribofuranosylbenzimidazole;5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem;5,6-Dichlorobenzimidazole riboside;5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII;DRB
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB550.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 222-224°C |
| Boiling point: | 606.2±65.0 °C(Predicted) |
| Density | 1.5917 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 20 mg/ml) |
| pka | 13.23±0.70(Predicted) |
| form | White solid |
| color | White |
| Water Solubility | Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers. |
| λmax | 296nm(lit.) |
| BRN | 39123 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | XHSQDZXAVJRBMX-AYLPWXGPSA-N |
| CAS DataBase Reference | 53-85-0 |
Description and Uses
DRB (53-85-0) is a classic inhibitor of transcription by RNA polymerase II.?A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2?Also inhibits casein kinase II, IC50=4-10 μM.?3?Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4?Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:
- as an inhibitor of RNA polymerase II in mouse melanoma cells
- for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
- in the inhibition of interleukin-2 gene transcription in Jurkat cells
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | DD7310000 |
| HS Code | 29349990 |
