(S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one , 95% , 32780-06-6

Synonym(s):
(S)-γ-Hydroxymethyl-γ-butyrolactone;(S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone;(S)-5-Hydroxymethyl-2-oxotetrahydrofuran

CAS NO.：32780-06-6

Empirical Formula: C5H8O3

Molecular Weight: 116.12

MDL number: MFCD00066224

PRODUCT Properties

• Melting point: 72-74 °C
• Boiling point: 110-115 °C/0.2 mmHg (lit.)
• alpha: 56 º (c=3 in chloroform)
• Density: 1.237 g/mL at 25 °C (lit.)
• refractive index: n20/D 1.471(lit.)
• Flash point: >230 °F
• storage temp.: 2-8°C
• pka: 14.12±0.10(Predicted)
• form: clear liquid
• color: Colorless to Almost colorless
• optical activity: [α]20/D +56°, c = 3 in chloroform
• BRN: 1680284
• CAS DataBase Reference: 32780-06-6(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2',3'-dideoxyribonolactone(32780-06-6)

Description and Uses

(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone can be used as a chiral synthon to synthesize:

• Potent nucleoside, acetylcholine, and (+)-muricatacin analogs.
• Mevinic acids, which are LDL cholesterol-lowering agents.
• Adenine based anti-HIV agent named β-F-ddA.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 23-24/25-37/39-26
• WGK Germany: 3
• HS Code: 29322090