Deoxyarbutin , ≥98% , 53936-56-4
CAS NO.：53936-56-4
Empirical Formula: C11H14O3
Molecular Weight: 194.23
MDL number: MFCD09970981
EINECS: 1308068-626-2
| Pack Size | Price | Stock | Quantity |
| 5g | RMB239.20 | In Stock |
|
| 25g | RMB599.20 | In Stock |
|
| 100g | RMB1599.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 88-89 °C(Solv: ligroine (8032-32-4)) |
| Boiling point: | 349.8±32.0 °C(Predicted) |
| Density | 1.174 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated) |
| pka | 10.10±0.15(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
Description and Uses
Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.
Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2932990090 |
