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A8440512

(±)-Sulfinpyrazone , ≥96% , 57-96-5

Synonym(s):
(±)-Sulfinpyrazone;1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione;Diphenylpyrazone

CAS NO.:57-96-5

Empirical Formula: C23H20N2O3S

Molecular Weight: 404.48

MDL number: MFCD00057279

EINECS: 200-357-4

Pack Size Price Stock Quantity
1G RMB23.20 In Stock
5G RMB43.20 In Stock
25G RMB158.40 In Stock
100g RMB479.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 136-137°
Boiling point: 590.8±42.0 °C(Predicted)
Density  1.1890 (rough estimate)
refractive index  1.6360 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Very slightly soluble in water, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
form  Solid
pka pKa 2.8(H2O t = RT I undefined) (Uncertain)
color  Off-White to Light Brown
Water Solubility  2.601g/L(22 ºC)
CAS DataBase Reference 57-96-5(CAS DataBase Reference)
NIST Chemistry Reference Sulfinpyrazone(57-96-5)

Description and Uses

Sulfinpyrazone is soluble in alkaline solutions. Its synthesis is similar to that of phenylbutazone (Fig. 36.33). It produces its uricosuric effect in a manner similar to that of probenecid. A dose of 35 mg produces a uricosuric effect equivalent to that produced by 100 mg of probenecid, whereas 400 mg/day of sulfinpyrazone produces an effect comparable to that obtained with doses of 1.5 to 2 g of probenecid. It also possesses, not surprisingly, some of the properties of phenylbutazone. It is an inhibitor of human platelet prostaglandin synthesis at the cyclooxygenase step, resulting in a decrease in platelet release and a reduction in platelet aggregation. This antiplatelet effect suggests a role for sulfinpyrazone in reducing the incidence of sudden death, which can occur in the first year following a myocardial infarction; however, it lacks the analgetic and anti-inflammatory effects of phenylbutazone.

Sulfinpyrazone is used in the treatment of gout acting as a uricosuric medication.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  UQ8575000
HS Code  2933194350
Hazardous Substances Data 57-96-5(Hazardous Substances Data)

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