Xanthophyll , 75% , 127-40-2

Synonym(s):
Lutein;Xanthophyll solution;α-Carotene-3,3′-diol;β, ε-carotene;β, ε-carotene-3,3′-diol

CAS NO.：127-40-2

Empirical Formula: C40H56O2

Molecular Weight: 568.87

MDL number: MFCD08435941

EINECS: 204-840-0

PRODUCT Properties

• Melting point: 195 °C
• alpha: 18Cd +165° (c = 0.7 in benzene)
• Boiling point: 572.66°C (rough estimate)
• Density: 0.9944 (rough estimate)
• refractive index: n20/D1.361-1.363
• Flash point: 269.1±27.5 °C
• storage temp.: -20°C
• solubility: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly, Heated, Sonicated)
• pka: 14.61±0.70(Predicted)
• form: Solid
• color: Red to Very Dark Red
• optical activity: 〔α〕656.3 +16220 (c 0.2, CHCl3)
• λmax: λ: 441-451 nm Amax
• Merck: 13,10120
• BRN: 2068547
• Stability: Light Sensitive, Temperature Sensitive
• InChIKey: KBPHJBAIARWVSC-RGZFRNHPSA-N
• LogP: 11.524 (est)
• CAS DataBase Reference: 127-40-2(CAS DataBase Reference)
• EPA Substance Registry System: .beta.,.epsilon.-Carotene-3,3'-diol, (3R,3'R,6'R)- (127-40-2)

Description and Uses

Lutein is a dietary carotenoid that has been found in eggs and yellow-colored fruits and vegetables and has diverse biological activities. It reduces hyperglycemia-induced mitochondrial DNA damage and production of reactive oxygen species (ROS) and promotes mitochondrial biogenesis in ARPE-19 cells when used at a concentration of 10 μM. Lutein (20 mg/kg) increases nitric oxide (NO) production and decreases serum levels of endothelin-1 in a rat model of hyperhomocysteinemia. Dietary administration of lutein (0.2%) decreases monocyte migration and lesion size in an ApoE^-/- and Ldlr^-/- mouse models of atherosclerosis. Lutein reduces infarct size and cardiac malondialdehyde (MDA), lactate dehydrogenase (LDH), and troponin T levels, and increases cardiac levels of catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and Nrf2 in a rat model of heart failure induced by isoproterenol . It forms a retinal pigment in human eyes, and high dietary intake of lutein is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans.

Xanthophyll is one of the most widespread carotenoid alcohols in nature. Originally isolated from egg yolk, also isolated by chromatography from nettles, algae, and petals of many yellow flowers.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319
• Precautionary statements: P210-P280-P305+P351+P338-P337+P313-P403+P235
• Hazard Codes: Xi
• Risk Statements: 36/37/38-11
• Safety Statements: 26-37/39-16-7-24/25
• WGK Germany: 3
• F: 1-8-10-16
• HS Code: 29061990