Home Categories 2-Acetylphenothiazine
A8417212

2-Acetylphenothiazine , 95% , 6631-94-3

Synonym(s):
NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine;NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem

CAS NO.:6631-94-3

Empirical Formula: C14H11NOS

Molecular Weight: 241.31

MDL number: MFCD00005017

EINECS: 229-626-4

Pack Size Price Stock Quantity
1g RMB47.20 In Stock
5g RMB151.20 In Stock
25G RMB599.20 In Stock
100G RMB1919.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 180-185 °C (lit.)
Boiling point: 455.7±34.0 °C(Predicted)
Density  1.249±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly, Heated)
pka -2.45±0.20(Predicted)
form  Dark yellow-orange powder
color  Yellow to Dark Orange
λmax 244nm(MeOH)(lit.)

Description and Uses

2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.

2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H412
Precautionary statements  P273
Hazard Codes  Xn
Risk Statements  22-52/53
Safety Statements  60-61
WGK Germany  3
HS Code  2934309090

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