Withaferin A , Analysis standard , 5119-48-2

Synonym(s):
4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone;5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide;Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem;Withaferine;Withaferine A

CAS NO.：5119-48-2

Empirical Formula: C28H38O6

Molecular Weight: 470.6

MDL number: MFCD10687098

EINECS: 999-999-2

PRODUCT Properties

• Melting point: 252-253℃
• alpha: D28 +125° (c = 1.30 in CHCl3)
• Boiling point: 680.7±55.0 °C(Predicted)
• Density: 1.28
• Flash point: 226℃
• storage temp.: Desiccate at -20°C
• solubility: Soluble in DMSO (up to 20 mg/ml)
• pka: 13.49±0.70(Predicted)
• form: White solid
• color: White
• biological source: plant (Withania somnifera)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
• InChIKey: DBRXOUCRJQVYJQ-CKNDUULBSA-N

Description and Uses

Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro?(IC50?= 12 nM) and?in vivo.1?Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2?Covalently binds to the intermediate filament protein, vimentin3?inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in?in vivo?models.5

Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P271-P280
• Hazard Codes: T
• WGK Germany: 3
• RTECS: KE7288500
• HS Code: 29322090