Vincristine sulfate salt , Analysis of standards,> 99% , 2068-78-2

Synonym(s):
22-Oxovincaleukoblastine sulfate salt;Leurocristine sulfate salt;V5 Tag Peptide;VCR;Vincristine sulfate salt

CAS NO.：2068-78-2

Empirical Formula: C46H58N4O14S

Molecular Weight: 923.04

MDL number: MFCD08706469

EINECS: 218-190-0

PRODUCT Properties

• Melting point: 300 °C
• Boiling point: 273-281 °C
• alpha: D26 +8.5° (c = 0.8)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: methanol: soluble20mg/mL
• form: lyophilized powder
• color: white to off-white
• Water Solubility: >=1 g/100 mL at 24 ºC
• BRN: 3924631
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
• InChIKey: AQTQHPDCURKLKT-HSMPTBRCNA-N

Description and Uses

Vincristine sulfate (2068-78-2) arrests cell cycle at G2/M by interfering with mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins.1,2?Induces apoptosis.3?Vincristine sulfate is a clinically useful cancer chemotherapeutic agent.

Vincristine sulfate, is used as an anticancer agent, microtubule disrupter, Induces apoptosis in human lymphoma cells. Other applications include as a cell cycle arresting, apoptotic inducing alkaloid.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H341-H361fd
• Precautionary statements: P202-P264-P270-P280-P301+P310-P405
• Hazard Codes: T
• Risk Statements: 61-36/37/38-63-23/24/25-68-62-25
• Safety Statements: 22-24/25-53-45-37/39-26-36/37/39-36/37
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: OH6340000
• F: 8-10
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29399990
• Toxicity: LD50 intraperitoneal in mouse: 3mg/kg