Home Categories API 1-<WBR>(2,3,4-<WBR>Trimethoxybenzyl)<WBR>piperazine dihydrochloride
A8024212

1-<WBR>(2,3,4-<WBR>Trimethoxybenzyl)<WBR>piperazine dihydrochloride , 97% , 13171-25-0

Synonym(s):
Trimetazidine dihydrochloride

CAS NO.:13171-25-0

Empirical Formula: C14H24Cl2N2O3

Molecular Weight: 339.26

MDL number: MFCD00243086

EINECS: 236-117-0

Pack Size Price Stock Quantity
5g RMB73.60 In Stock
10G RMB127.20 In Stock
25G RMB236.00 In Stock
100g RMB889.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 231-235 °C(lit.)
storage temp.  Refrigerator
solubility  Freely soluble in water, sparingly soluble in alcohol.
form  Solid
color  White to Off-White
Merck  14,9705
Stability: Hygroscopic
InChIKey XIRALXKCBGTYSC-UHFFFAOYSA-N
CAS DataBase Reference 13171-25-0(CAS DataBase Reference)

Description and Uses

Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.

1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:

  • Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
  • Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  TM2976100
HazardClass  IRRITANT
HS Code  29339900
Toxicity LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)

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