A7975012
3-(Trifluoromethyl)phenyl Isocyanate , >96.0%(GC) , 329-01-1
Synonym(s):
α,α,α-Trifluoro-m-tolyl isocyanate
CAS NO.：329-01-1
Empirical Formula: C8H4F3NO
Molecular Weight: 187.12
MDL number: MFCD00002020
EINECS: 206-341-3
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | -26 °C |
| Boiling point: | 54 °C11 mm Hg(lit.) |
| Density | 1.359 g/mL at 25 °C(lit.) |
| vapor pressure | 2.44 psi ( 20 °C) |
| refractive index | n |
| Flash point: | 138 °F |
| storage temp. | Keep Cold |
| solubility | soluble in Toluene |
| form | clear liquid |
| Specific Gravity | 1.359 |
| color | Colorless to Almost colorless |
| Water Solubility | 5.46g/L at 25℃ |
| Sensitive | Lachrymatory |
| BRN | 744880 |
| LogP | 2.04 |
Description and Uses
3-?(Trifluoromethyl)?phenyl Isocyanate is a reagent used in the synthesis of heme-regulated inhibitor as selective activators of the eukaryotic inhibition factor Alpha (eIF2α) phosphorylation arm of the endoplasmic reticulum stress response. Influences cell proliferation, cell differentiaton and adaptation to stress. Also a reagent in the preparation of sorafenib derivatives.
Safety
| Symbol(GHS) |     GHS02,GHS05,GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H226-H302-H311-H315-H317-H318-H330-H335-H411 |
| Precautionary statements | P210-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | Xn,T,T+ |
| Risk Statements | 20/22-37/38-42-36/37/38-26-21/22-22 |
| Safety Statements | 23-28-45-36/37/39-28A-26-36/37-22-9 |
| RIDADR | UN 3384 6.1/PG 1 |
| WGK Germany | 2 |
| RTECS | NR0200000 |
| F | 10 |
| Hazard Note | Toxic/Lachrymatory/Keep Cold |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29291090 |
