Trifluoperazine Dihydrochloride , >98.0%(HPLC)(T) , 440-17-5

Synonym(s):
10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride;Trifluoperazine dihydrochloride

CAS NO.：440-17-5

Empirical Formula: C21H26Cl2F3N3S

Molecular Weight: 480.42

MDL number: MFCD00012656

EINECS: 207-123-0

PRODUCT Properties

• Melting point: 243 °C (dec.)(lit.)
• Flash point: 9℃
• storage temp.: -20°C
• solubility: ethanol: soluble5mg/mL
• pka: pK1 3.9, pK2 8.1(at 25℃)
• form: powder
• color: white to off-white
• λmax: 312nm(MeOH)(lit.)
• Merck: 14,9680
• BRN: 3820024
• Stability: Hygroscopic
• CAS DataBase Reference: 440-17-5(CAS DataBase Reference)
• EPA Substance Registry System: 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5)

Description and Uses

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α₁ over the α₂ subtypes (K_is = 24, 653, 163, and 391 nM for α_1A, α_2A, α_2B, and α_2C, respectively). TFP binds with much higher affinity to the dopamine D₂-like receptor (K_d = 0.96 nM) compared to the dopamine D₄-like and the serotonin 5-HT_2A receptors (K_ds = 44 and 135 nM, respectively). Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ). TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.

Antipsychotic

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H302-H319-H336-H341-H372-H410
• Precautionary statements: P201-P273-P301+P312+P330-P305+P351+P338-P308+P313
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: SP1750000
• F: 3-10
• HS Code: 29343000