Triisopropylsilyl Trifluoromethanesulfonate , 98% , 80522-42-5

Synonym(s):
TIPS triflate;Trifluoromethanesulfonic acid triisopropylsilyl ester;Triisopropylsilyl triflate

CAS NO.：80522-42-5

Empirical Formula: C10H21F3O3SSi

Molecular Weight: 306.42

MDL number: MFCD00009913

EINECS: 638-988-6

PRODUCT Properties

• Boiling point: 45-46 °C/0.03 mmHg
• Density: 1.14 g/mL at 25 °C (lit.)
• refractive index: n20/D 1.415(lit.)
• Flash point: 213 °F
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: Miscible with chloroform and ethyl acetate.
• form: Liquid
• Specific Gravity: 1.14
• color: Clear light brown to orange-brown
• Sensitive: Moisture Sensitive
• Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents
• BRN: 3591541
• InChI: InChI=1S/C10H21F3O3SSi/c1-7(2)18(8(3)4,9(5)6)16-17(14,15)10(11,12)13/h7-9H,1-6H3
• InChIKey: LHJCZOXMCGQVDQ-UHFFFAOYSA-N
• SMILES: C(F)(F)(F)S(O[Si](C(C)C)(C(C)C)C(C)C)(=O)=O

Description and Uses

Triisopropylsilyl trifluoromethanesulfonate is used as a reagent for the introduction of triisopropylsilyl(TIPS) group in organic synthesis. It is involved in the synthesis of 2-substituted benzothiopyran-4-ones and silyloxy acetylenes. As a protecting group in organic synthesis, it is utilized especially for the protection of primary amines. Furthermore, it plays an important role in Takahashi Taxol total synthesis or for chemical glycosylation reactions.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H314
• Precautionary statements: P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
• Hazard Codes: C
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45-28A-27
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 3-10-21
• TSCA: No
• HazardClass: 8
• PackingGroup: II
• HS Code: 29319090