Tetraethyl methylenediphosphonate , ≥98% , 1660-94-2

Synonym(s):
Bis(diethoxyphosphinyl)methane;Methylenediphosphonic acid tetraethylester;NSC 133889

CAS NO.：1660-94-2

Empirical Formula: C9H22O6P2

Molecular Weight: 288.21

MDL number: MFCD00039887

EINECS: 216-764-5

PRODUCT Properties

• Boiling point: 171-174 °C11 mm Hg(lit.)
• Density: 1.16 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.442(lit.)
• Flash point: >230 °F
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Chloroform (Sparingly), Methanol (Slightly)
• form: Liquid
• Specific Gravity: 1.160
• color: Clear yellow to yellow-brown
• Water Solubility: Slightly miscible with water.
• BRN: 1813241
• InChIKey: STJWVOQLJPNAQL-UHFFFAOYSA-N

Description and Uses

Reactant for synthesis of:

• Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
• Unnatural alpha-amino acid derivatives containing gem-biphosphonates
• Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
• Lycopene via Wittig-Horner reaction
• Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
• Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase

Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P280g-P305+P351+P338
• Hazard Codes: Xi,C
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: SZ9150000
• Hazard Note: Corrosive
• TSCA: Yes
• HS Code: 29319090
• Toxicity: mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03139,