TAE226 (NVP-TAE226) , ≥99% , 761437-28-9
CAS NO.：761437-28-9
Empirical Formula: C23H25ClN6O3
Molecular Weight: 468.94
MDL number: MFCD12031516
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB758.40 | In Stock |
|
| 10MG | RMB1092.80 | In Stock |
|
| 50MG | RMB4983.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.349 |
| storage temp. | Store at -20°C |
| solubility | ≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 14.57±0.46(Predicted) |
| color | White to khaki |
Description and Uses
NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC50 = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC50 = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC50 = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.
NVP-TAE 226 is FAK and IGF-IR inhibitor. It can be used in biological study and therapeutic use of TAE226, a bis-?anilino pyrimidine compound, inhibits the egfr-?mutant kinase including T790M mutant to show anti-?tumor effect on EGFR-?mutant non-?small cell lung cancer cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
