Torsemide , ≥98%(HPLC) , 56211-40-6

Synonym(s):
Demadex;N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

CAS NO.：56211-40-6

Empirical Formula: C16H20N4O3S

Molecular Weight: 348.42

MDL number: MFCD00866166

EINECS: 637-197-3

PRODUCT Properties

• Melting point: 163-164°C
• Density: 1.283±0.06 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO: soluble18mg/mL
• pka: 6.44(at 25℃)
• form: solid
• color: White
• Water Solubility: Soluble
• Merck: 14,9552
• BCS Class: 1
• InChIKey: NGBFQHCMQULJNZ-UHFFFAOYSA-N
• CAS DataBase Reference: 56211-40-6(CAS DataBase Reference)
• EPA Substance Registry System: 3-Pyridinesulfonamide, N-[[(1-methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]- (56211-40-6)

Description and Uses

Torasemide is a novel loop diuretic launched in 1993 after a 12-year gap from the last diuretic introduction. It is indicated for the treatment of hypertension and edema associated with chronic congestive heart failure, renal disease and hepatic cirrhosis. Torasemide exerts its major diuretic activity on the thick ascending limb of the Henle's loop to promote rapid and marked excretion of water, Na⁺, Cl^-, and to a lesser extent,K⁺ and Ca²⁺. Compared with other loop diuretics such as furosemide, torasemide has a stronger antihypertensive action, a higher bioavailability, a longer duration of action that is independent of the renal function, and has no side effects such as paradoxical antidiuresis. The mechanism of its vasodilating effect has been suggested to result from, at least in part, the competitive antagonism of the thromboxane A2 receptor.

Torasemide is a loop diuretic. Diuretics have been abused as performance-enhancing drugs and masking agents in doping in sports. Use of torsemide is effective for the treatment of edema associated with chronic renal failure. The pharmacology of torasemide is similar to that of frusemide,though torasemide has a longer duration of action with a plasma half-life of approximately 3.5 hours. It also causes a less marked loss of potassiumand calcium.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H319-H361fd
• Precautionary statements: P201-P202-P264-P280-P305+P351+P338-P308+P313
• Hazard Codes: Xi
• Risk Statements: 36-36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 2
• RTECS: UT7938000
• HS Code: 2935904000