Torin 1 , ≥97% , 1222998-36-8

Synonym(s):
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one, DNA-PK Inhibitor VI, PI 3-K Inhibitor XVIII;mTOR Inhibitor XI, Torin1 - Calbiochem

CAS NO.：1222998-36-8

Empirical Formula: C35H28F3N5O2

Molecular Weight: 607.62

MDL number: MFCD18782653

PRODUCT Properties

• Melting point: >223°C (dec.)
• Boiling point: 817.2±65.0 °C(Predicted)
• Density: 1.362
• storage temp.: +2C to +8C
• solubility: Soluble in DMSO (up to 8 mg/ml).
• form: Yellowish-white powder
• pka: 4.19±0.20(Predicted)
• color: White or off-white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Description and Uses

Torin1 (1222998-36-8) is a potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively.1,2 Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg).2 Induces autophagy.3 Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models.4 Downregulates NGF expression in RSC96 cells.5

Torin 1 is a potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H320-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• Safety Statements: 24/25
• HS Code: 29334900