A7819812
Tyrphostin 9 , ≥98% , 10537-47-0
Synonym(s):
[[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;AG 17 - CAS 10537-47-0 - Calbiochem;Malonoben;NSC 242557, 3,5-di- t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di- t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB159.20 | In Stock |
|
| 50MG | RMB289.60 | In Stock |
|
| 100MG | RMB591.20 | In Stock |
|
| 500MG | RMB1975.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 141-143℃ (ethanol ) |
| Boiling point: | 424.99°C (rough estimate) |
| Density | 1.0741 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | ethanol: 20 mg/mL |
| form | solid |
| pka | 7.55±0.40(Predicted) |
| color | yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 10537-47-0(CAS DataBase Reference) |
| EPA Substance Registry System | Malonoben (10537-47-0) |
Description and Uses
Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4
Selective inhibitor of PDGF receptor tyrosine kinase
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301+H311 |
| Precautionary statements | P264-P270-P280-P301+P310-P302+P352+P312-P361+P364 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | OO3737000 |
| HS Code | 2926.90.5050 |
| HazardClass | 6.1 |
