Terbinafine HCl , ≥98% , 78628-80-5

Synonym(s):
trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride

CAS NO.：78628-80-5

Empirical Formula: C21H26ClN

Molecular Weight: 327.89

MDL number: MFCD00145430

EINECS: 616-640-4

PRODUCT Properties

• Melting point: 204-208°C
• storage temp.: 15-25°C
• solubility: methanol: soluble50mg/mL
• form: powder
• color: white
• Merck: 14,9156
• BCS Class: 1
• InChI: InChI=1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+
• InChIKey: BWMISRWJRUSYEX-SZKNIZGXSA-N
• SMILES: C12C=CC=CC1=CC=CC=2CN(C)C/C=C/C#CC(C)(C)C.Cl
• CAS DataBase Reference: 78628-80-5(CAS DataBase Reference)

Description and Uses

Terbinafine hydrochloride is the first orally active allylamine antifungal with 30-fold greater antifungal activity than naftifine. The compound is indicated for the treatment of ringworm and fungal nail infections. Terbinatine hydrochloride acts on a single fungal enzyme, squalene epoxidase, interfering with the biosynthesis of ergosterols in cell membranes. Unlike other antifungal agents, it does not inhibit cytochrome P450 enzymes.

An orally active, antimycotic allylamine related to Naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. Antifungal.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H315-H319-H335-H410
• Precautionary statements: P261-P264-P271-P273-P302+P352-P305+P351+P338
• Hazard Codes: Xi,N
• Risk Statements: 36/37/38-50/53
• Safety Statements: 26-36/37/39-61-60
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• RTECS: QJ8600100
• HS Code: 29214990
• Toxicity: LD50 in mice, rats (mg/kg): 4000, 4000 orally; 393, 213 i.v. (Ganzinger)