TPCA-1 , ≥98% , 507475-17-4
Synonym(s):
[5-( p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide, TPCA-1;[5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide;IKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem
CAS NO.：507475-17-4
Empirical Formula: C12H10FN3O2S
Molecular Weight: 279.29
MDL number: MFCD09037541
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB386.40 | In Stock |
|
| 25MG | RMB1359.20 | In Stock |
|
| 100MG | RMB3424.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >217°C (dec.) |
| Boiling point: | 442.6±45.0 °C(Predicted) |
| Density | 1.490 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear |
| pka | 13.12±0.50(Predicted) |
| form | powder |
| color | white to light brown |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
TPCA-1 (507475-17-4) selective inhibitor of IκB kinase 2 (IKK2) (IC50 = 17.9 nM).1 Inhibits production of pro-inflammatory cytokines in arthritis and other animal models of inflammation.1,2 Also attenuates NLRP3 inflammasome activation in THP-1 myeloid cells, and suppresses IL1β-induced proliferation, migration, and invasion of HeLa cells.3,4 Continuous exposure to TPCA-1 promotes expansion of hematopoietic stem/progenitor cells (HSPCs) via improved glycolysis and limited ROS production.5
TPCA-1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCA-1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.
