Tadalafil , ≥99% , 171596-29-5

Synonym(s):
(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione;ICI-351;Tadalafil

CAS NO.：171596-29-5

Empirical Formula: C22H19N3O4

Molecular Weight: 389.4

MDL number: MFCD07771966

EINECS: 687-782-2

PRODUCT Properties

• Melting point: 298-300°C
• alpha: D20 +71.0°
• Boiling point: 679.1±55.0 °C(Predicted)
• Density: 1.51±0.1 g/cm3(Predicted)
• Flash point: 2℃
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO: soluble20mg/mL, clear
• form: powder
• pka: 16.68±0.40(Predicted)
• color: white to beige
• optical activity: [α]/D +68 to +78°, c = 1 in chloroform-d
• BCS Class: 4
• Stability: Unstable in Methanol
• InChI: InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
• InChIKey: WOXKDUGGOYFFRN-IIBYNOLFSA-N
• SMILES: N1C2=C(C=CC=C2)C2C[C@]3([H])C(=O)N(C)CC(=O)N3[C@H](C3=CC=C4OCOC4=C3)C1=2
• CAS DataBase Reference: 171596-29-5(CAS DataBase Reference)

Description and Uses

Tadalafil (market name “Cialis” or “Adcirca”) was developed by American pharmaceutical company Lilly. It is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension.The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.

Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P302+P352-P305+P351+P338
• Hazard Codes: F,Xn
• Risk Statements: 11-20/21/22-36
• Safety Statements: 16-36/37
• WGK Germany: 3
• RTECS: UQ4431050
• HS Code: 2934990002
• Hazardous Substances Data: 171596-29-5(Hazardous Substances Data)