Home Categories Biochemical Engineering N-p-Tosyl-L-phenylalanine chloromethyl ketone
A7795412

N-p-Tosyl-L-phenylalanine chloromethyl ketone , 97% , 402-71-1

Synonym(s):
(S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone;(S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone;Nα-Tosyl-Phe Chloromethyl Ketone;Tosyl-L-phenylalanyl-chloromethane;TPCK

CAS NO.:402-71-1

Empirical Formula: C17H18ClNO3S

Molecular Weight: 351.85

MDL number: MFCD00000935

EINECS: 206-954-6

Pack Size Price Stock Quantity
25mg RMB40.00 In Stock
100MG RMB102.40 In Stock
250MG RMB217.60 In Stock
1G RMB768.00 In Stock
5G RMB3288.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 106-108 °C(lit.)
Boiling point: 509.9±60.0 °C(Predicted)
Density  1.1350 (rough estimate)
refractive index  1.6100 (estimate)
storage temp.  -20°C
solubility  DMSO: >10 mg/mL stable for several months at 4°C.
form  powder
pka 8.71±0.50(Predicted)
color  white
BRN  2895215
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference 402-71-1
EPA Substance Registry System Benzenesulfonamide, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl- (402-71-1)

Description and Uses

TPCK (402-71-1) is an irreversible inhibitor of the serine protease chymotrypsin.1 It also inhibits certain cysteine proteases (bromelain, ficin, papain).1 TPCK inhibited (IC50 = 5 μM) the mitogen-induced activation of pp70s6k, a mitogen-regulated serine/threonine kinase involved in the G1 to S phase transition of the cell cycle.2

N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.

Safety

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H315-H318-H335
Precautionary statements  P280-P302+P352-P305+P351+P338+P310
Hazard Codes  Xi
Risk Statements  37/38-41
Safety Statements  26-36
RIDADR  UN 3335
WGK Germany  3
RTECS  XT5613500
10-19-21
TSCA  Yes
HS Code  29350090

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