Plerixafor8HCl(AMD31008HCl) , 10mMinWater , 155148-31-5
Synonym(s):
Plerixafor;1,1′-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride;1,1?(1,4-Phenylenebis(methylene))-bis-1,4,8,11-tetraazacyclotetradecane, 8HCl, 4H?O, 1,4-bis((1,4,8,11-Tetraazacyclotetradecan-1-yl)methyl)benzene, 8HCl, 4H?O;InSolution
CAS NO.：155148-31-5
Empirical Formula: C28H54N8
Molecular Weight: 502.78
MDL number: MFCD04974488
EINECS: 828-184-5
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB280.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 188 - 193°C (dec.) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | H2O: ≥10 mg/mL, clear |
| form | solid |
| color | White |
| Water Solubility | Soluble in water (100mM) |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. |
Description and Uses
Plerixafor (155148-31-5) is a highly selective CXCR4 antagonist (IC50 = 20-130 nM).1,2 Originally investigated as an HIV replication inhibitor.3 Plerixafor has been investigated for the treatment autoimmune diseases and various cancers.4 Clinically useful for the mobilization of hematopoietic stem cells in the treatment of blood cancers.
Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).
Safety
| Symbol(GHS) |   GHS05,GHS02 |
| Signal word | Danger |
| Hazard statements | H314-H226 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
