Hederagenin , 10mMinDMSO , 465-99-6

Synonym(s):
3,23-Dihydroxyolean-12-en-28-acid;Astrantiagenin E;Caulosapogenin;Hederagenic acid;Hederagenol

CAS NO.：465-99-6

Empirical Formula: C30H48O4

Molecular Weight: 472.71

MDL number: MFCD00017385

EINECS: 207-369-9

PRODUCT Properties

• Melting point: 332-334°
• alpha: D20 +81° (c = 0.7 in pyridine)
• Boiling point: 493.44°C (rough estimate)
• Density: 0.9871 (rough estimate)
• refractive index: 1.4800 (estimate)
• storage temp.: Sealed in dry,2-8°C
• solubility: methanol: soluble1mg/mL
• pka: 4.63±0.70(Predicted)
• form: Solid
• color: White to Off-White
• λmax: 405nm(H2SO4)(lit.)
• Merck: 14,4624
• InChIKey: PGOYMURMZNDHNS-MYPRUECHSA-N
• LogP: 7.410 (est)

Description and Uses

Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.

Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312+P330-P501
• Hazard Codes: Xi
• Risk Statements: 22
• Safety Statements: 22-45-24/25
• WGK Germany: 3
• HS Code: 29181990