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A7779458

Mebendazole , 10mMinDMSO , 31431-39-7

Synonym(s):
5-Benzoyl-2-benzimidazolecarbamic acid methyl ester;Mebendazol;Methyl N-(5-benzoyl-1H-benzimidazol-2-yl)carbamate

CAS NO.:31431-39-7

Empirical Formula: C16H13N3O3

Molecular Weight: 295.29

MDL number: MFCD00057872

EINECS: 250-635-4

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 288.5°C
Boiling point: 436.98°C (rough estimate)
Density  1.1952 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  Practically insoluble in water, in alcohol and in methylene chloride.
pka pKa 3.43/9.93(H2O,t =25,I=0.025) (Uncertain)
form  Solid
color  White to Pale Beige
Water Solubility  35.4mg/L(25 ºC)
Merck  14,5768
BRN  759809
BCS Class 2,4

Description and Uses

Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 μM for Giardia in vitro). As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration. Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation. Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.

For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 2811
WGK Germany  3
RTECS  EY8600000
HS Code  29339900
Toxicity LD50 orally: >80 mg/kg in sheep; >40 mg/kg in mice, rats and chickens (Van Gelder)

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