Home Categories Biochemical Engineering N,N-Bis(2-hydroxyethyl)glycine
A7778258

N,N-Bis(2-hydroxyethyl)glycine , 10mMinWater , 150-25-4

Synonym(s):
N,N-Bis(2-hydroxyethyl)glycine;BICINE;N,N- bis-(2-Hydroxyethyl)glycine;N,N-bis-(2-Hydroxyethyl)glycine;N,N-Bis(2-hydroxyethyl) glycine

CAS NO.:150-25-4

Empirical Formula: C6H13NO4

Molecular Weight: 163.17

MDL number: MFCD00004295

EINECS: 205-755-1

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 190 °C (dec.)(lit.)
Boiling point: 290.25°C (rough estimate)
Density  1.05 g/mL at 20 °C
vapor pressure  0.002-0.007Pa at 20-25℃
refractive index  1.4240 (estimate)
storage temp.  room temp
solubility  H2O: 1 M at 20 °C, clear, colorless
form  Powder
color  White
PH Range 7.6 - 9.0
PH 4.0-5.5 (25℃, 1M in H2O)
pka 8.3(at 25℃)
Water Solubility  soluble
λmax λ: 260 nm Amax: 0.070
λ: 280 nm Amax: 0.040
Merck  14,1201
BRN  1769362
LogP 2.3 at 20℃ and pH7
Surface tension 72.2mN/m at 1g/L and 20℃

Description and Uses

Bicine is an amino acid that results from amine degradation due to the presence of oxygen and/or sulfur dioxide. The amine solvents that undergo this degradation are MDEA, DEA, TEA, and mixed amine solvents containing any of these amines. As a zwitterionic amino acid buffer agent, bicine is active in the pH 7.6-9.0 range (pKa of 8.26 at 25°C). Bicine is a recommended buffer for low-temperature biochemical work. It is used for the preparation of stable substrate solution for serum guanase determination. It can be used as a nitrogenous strength enhancer to regulate cement hydration and improve cement properties. Studies have found that bicine significantly changes the morphology of portlandite crystals from a parallel-stacked lamellar shape to a distorted one and also decreases the pore size of the hardened cement paste at an early age[1]. In particular, bicine could promote the rapid formation of β-sheet-rich amyloid-β fibrils[2].

To prepare stable substrate solution for the determination of guanine deaminase. The buffer is widely used with the working concentration of 3-100mM.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  MB9700000
3-10
TSCA  Yes
HS Code  29225000
Toxicity mouse,LD50,intraperitoneal,1540mg/kg (1540mg/kg),KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)",Revue d'Epidemiologie, Medecine Sociale et Sante Publique. Vol. 10, Pg. 391, 1962.

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