Naproxen , 10mMinDMSO , 22204-53-1
Synonym(s):
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid;(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid;NAP;Naproxen
CAS NO.：22204-53-1
Empirical Formula: C14H14O3
Molecular Weight: 230.26
MDL number: MFCD00010500
EINECS: 244-838-7
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 152-154 °C (lit.) |
| alpha | D +66° (in chloroform) |
| Boiling point: | 332.25°C (rough estimate) |
| Density | 1.1450 (rough estimate) |
| refractive index | 67.5 ° (C=1, CHCl3) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol. |
| form | powder |
| pka | pKa 4.28± 0.02(H2O,t =25,I=0.01) (Uncertain) |
| color | White to Almost white |
| optical activity | [α]25/D +66°, c = 1 in chloroform |
| Water Solubility | Insoluble in water. |
| Merck | 14,6417 |
| BRN | 3591067 |
| BCS Class | 2 |
| LogP | 3.18 |
| CAS DataBase Reference | 22204-53-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Naproxen(22204-53-1) |
| EPA Substance Registry System | 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (.alpha.S)- (22204-53-1) |
Description and Uses
Naproxen is synthesized from 2-methoxynaphthalene and the (+)-isomer obtained by resolution with cinchonidine (61). It was introduced in the United States in 1976 and, as a generic drug, has consistently been among the more popular NSAIDs. It is marketed as the S-(+)-enantiomer, but interestingly, the sodium salt of the (–)-isomer also is on the market as Anaprox. As an inhibitor of prostaglandin biosynthesis, it is 12 times more potent than aspirin, 10 times more potent than phenylbutazone, three to four times more potent than ibuprofen, and four times times more potent than fenoprofen, but it is approximately 300 times less potent than indomethacin.
Being analogous to other drugs of this series, naproxene exhibits analgesic, fever-reducing, and long-lasting anti-inflammatory action. It causes reduction and removal of painful symptoms including joint pain, stiffness, and swelling in the joints. It is used in the same indications as ibuprofen.
Safety
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H361fd-H411 |
| Precautionary statements | P202-P273-P301+P312-P302+P352-P305+P351+P338-P308+P313 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-39/23/24/25-23/24/25-11-36/37/38 |
| Safety Statements | 36/37-45-16-7-26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UF5275000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29189900 |
| Hazardous Substances Data | 22204-53-1(Hazardous Substances Data) |
| Toxicity | LD50 in mice (mg/kg): 435 i.v.; 1234 orally; in rats (mg/kg): 575 i.p.; 534 orally (Roszkowski) |
