Pramipexoledihydrochloride , 10mMinDMSO , 104632-25-9
Synonym(s):
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino) benzothiazole dihydrochloride;(S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride;PPX dihydrochloride;Pramipexole dihydrochloride monohydrate
CAS NO.:104632-25-9
Empirical Formula: C10H19Cl2N3S
Molecular Weight: 284.25
MDL number: MFCD00876894
EINECS: 629-842-2
Pack Size | Price | Stock | Quantity |
1ml | RMB559.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 288-290°C |
storage temp. | 2-8°C |
solubility | H2O: >20mg/mL |
form | powder |
color | white to off-white |
InChIKey | QMNWXHSYPXQFSK-KLXURFKVSA-N |
CAS DataBase Reference | 104632-25-9(CAS DataBase Reference) |
Description and Uses
(S)-Pramipexole is a dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPγS binding assay). It is also a partial agonist of α2A-adrenergic receptors (α2A-ARs; EC50 = 3,548.13 nM). (S)-Pramipexole is selective for dopamine D2-4 receptors (Kis = 954.99, 1,698.24, 12.59, 128.82 nM for for D2S, D2L, D3, and D4 receptors, respectively, in a radioligand binding assay) over D1 and D5 receptors (Kis = >10,000 nM for both). It prevents MPTP-induced decreases in the number of dopaminergic neurons in the substantia nigra pars compacta in common marmosets when administered at a dose of 60 μg/kg per day before, during, and after administration of MPTP. Formulations containing (S)-pramipexole have been used in the treatment of Parkinson''s disease and restless legs syndrome.
A dopamine-D2-receptor agonist. Antiparkinsonian.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302-H336 |
Precautionary statements | P261-P264-P270-P271-P301+P312-P304+P340+P312 |
WGK Germany | 3 |