Pramipexoledihydrochloride , 10mMinDMSO , 104632-25-9

Synonym(s):
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino) benzothiazole dihydrochloride;(S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride;PPX dihydrochloride;Pramipexole dihydrochloride monohydrate

CAS NO.：104632-25-9

Empirical Formula: C10H19Cl2N3S

Molecular Weight: 284.25

MDL number: MFCD00876894

EINECS: 629-842-2

PRODUCT Properties

• Melting point: 288-290°C
• storage temp.: 2-8°C
• solubility: H2O: >20mg/mL
• form: powder
• color: white to off-white
• InChIKey: QMNWXHSYPXQFSK-KLXURFKVSA-N

Description and Uses

(S)-Pramipexole is a dopamine D_2S, D_2L, D₃, and D₄ receptor agonist (EC₅₀s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [³⁵S]GTPγS binding assay). It is also a partial agonist of α_2A-adrenergic receptors (α_2A-ARs; EC₅₀ = 3,548.13 nM). (S)-Pramipexole is selective for dopamine D_2-4 receptors (K_is = 954.99, 1,698.24, 12.59, 128.82 nM for for D_2S, D_2L, D₃, and D₄ receptors, respectively, in a radioligand binding assay) over D₁ and D₅ receptors (K_is = >10,000 nM for both). It prevents MPTP-induced decreases in the number of dopaminergic neurons in the substantia nigra pars compacta in common marmosets when administered at a dose of 60 μg/kg per day before, during, and after administration of MPTP. Formulations containing (S)-pramipexole have been used in the treatment of Parkinson''s disease and restless legs syndrome.

A dopamine-D2-receptor agonist. Antiparkinsonian.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H336
• Precautionary statements: P261-P264-P270-P271-P301+P312-P304+P340+P312
• WGK Germany: 3