HydralazineHCl , 2mMinWater , 304-20-1

Synonym(s):
1-Hydrazinophthalazine hydrochloride;Hydralazine hydrochloride

CAS NO.：304-20-1

Empirical Formula: C8H9ClN4

Molecular Weight: 196.64

MDL number: MFCD00135998

EINECS: 206-151-0

PRODUCT Properties

• Melting point: 273°C
• Boiling point: 322.13°C (rough estimate)
• Density: 1.2961 (rough estimate)
• refractive index: 1.6110 (estimate)
• storage temp.: 2-8°C
• solubility: Soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in methylene chloride
• form: Solid
• color: White to Almost white
• PH: pH (20g/l, 25℃) : 3.5～4.5
• Water Solubility: Soluble in water. Slightly soluble in diethyl ether and alcohol.
• Merck: 14,4763
• BRN: 3568329
• BCS Class: 3
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: ZUXNZUWOTSUBMN-UHFFFAOYSA-N
• CAS DataBase Reference: 304-20-1(CAS DataBase Reference)
• EPA Substance Registry System: 1(2H)-Phthalazinone, hydrazone, monohydrochloride (304-20-1)

Description and Uses

Hydralazine is an orally bioavailable vasodilator and antihypertensive agent. It decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular production of reactive oxygen species (ROS) in rat macrophages activated by phorbol 12-myristate 13-acetate (PMA; ) at a concentration of 100 μM. Hydralazine (100 μM) also decreases nitric oxide production and mRNA expression of inducible nitric oxide synthase (iNOS) in rat macrophages activated by LPS (Item Nos. 19660| 19661| 19662) and interferon-γ (IFN-γ). It reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine (; IC₅₀s = 2.2 and 3.06 mM, respectively). Hydralazine (2.6 mg/kg) lowers mean arterial blood pressure (MAP) by 41.76% in conscious rats. Formulations containing hydralazine have been used in the treatment of high blood pressure and heart failure.

Hydralazine is a non-nucleoside analog that inhibits DNA methylation and reactivates the expression of tumor suppressor genes. Non-selective MAO-A/B inhibitor; semicarbazide-sensitive amine oxidase inhibitor. Antihypertensive.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H315-H319-H335
• Precautionary statements: P301+P330+P331+P310-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: TH9000000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29339900
• Hazardous Substances Data: 304-20-1(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: 280mg/kg