Thiamine nitratel , Analysis standard , 532-43-4

Synonym(s):
Thiamine nitrate;Vitamin B1 mononitrate;Vitamin B1 nitrate

CAS NO.：532-43-4

Empirical Formula: C12H17N5O4S

Molecular Weight: 327.36

MDL number: MFCD00036330

EINECS: 208-537-4

Pack Size	Price	Stock	Quantity
250MG	RMB143.20	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	374-392 °C
storage temp.	2-8°C
solubility	Sparingly soluble in water, freely soluble in boiling water, slightly soluble in alcohol and in methanol.
pka	4.8(at 25℃)
form	solid
color	White to Off-White
Odor	wh. cryst. or cryst. powd., sl. char. odor
Merck	14,9295
BRN	3857790
Stability:	Stable. Incompatible with strong oxidizing agents.
InChI	InChI=1S/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1
InChIKey	UIERGBJEBXXIGO-UHFFFAOYSA-N
SMILES	[N+]1(CC2=CN=C(C)N=C2N)C(C)=C(SC=1)CCO.[N+]([O-])([O-])=O

Description and Uses

Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro when used at concentrations ranging from 1 to 100 μM. In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication. It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice. Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3^-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).

Vitamin B1.