PRODUCT Properties
| Melting point: | 168℃ |
| Boiling point: | 436.5±45.0 °C(Predicted) |
| Density | 1.42 |
| storage temp. | 2-8°C |
| solubility | DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic) |
| form | powder |
| pka | 8.67±0.40(Predicted) |
| color | Yellow-brown |
Description and Uses
The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth., is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C (dec.) and a hydrobromide, m.p. 269°C (dec.).
Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.
