6α-Methyl-11β-hydroxyprogesterone , 10mMinDMSO , 2668-66-8

CAS NO.：2668-66-8

Empirical Formula: C22H32O3

Molecular Weight: 344.5

MDL number: MFCD00056477

EINECS: 220-208-7

PRODUCT Properties

• Melting point: 155-158°
• alpha: D +189° (in chloroform)
• Boiling point: 492.3±45.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated)
• form: Solid
• pka: 14.53±0.70(Predicted)
• color: White to Off-White

Description and Uses

6α-methyl-11β-hydroxy Progesterone is an anti-inflammatory steroid. It is a hydroxylated progesterone that lacks progestational and androgenic activity. It inhibits phytohemagglutinin-activated T cell proliferation in vitro with an IC₅₀ value of 2.9 μg/ml. 6α-methyl-11β-hydroxy Progesterone also inhibits TNF-α production in LPS-stimulated THP-1 cells (IC₅₀ = 30.54 μg/ml). Topical formulations containing 6α-methyl-11β-hydroxyprogesterone have been used to treat inflammatory ocular diseases.

glucocorticoid

Safety

• WGK Germany: 3
• RTECS: TU5250000