β-Nicotinamideadeninedinucleotide（NAD） , 10mMinWater , 53-84-9
Synonym(s):
NAD;DPN;β-NAD;Nadide;β-Nicotinamide adenine dinucleotide hydrate
CAS NO.：53-84-9
Empirical Formula: C21H27N7O14P2
Molecular Weight: 663.43
MDL number: MFCD02688274
EINECS: 200-184-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 140-142 °C (decomp) |
| alpha | D20 -31.5° (c = 1.2 in water) |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL |
| form | Powder |
| color | White |
| PH | ~3.0 (50mg/mL in water) |
| Odor | Odorless |
| Water Solubility | Soluble in water at 50mg/ml |
| Merck | 14,6344 |
| BRN | 3584133 |
| Stability: | Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| EPA Substance Registry System | Adenosine 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-84-9) |
Description and Uses
β-Nicotinamide adenine dinucleotide (NAD+) plays a major role in metabolism as a cofactor and mobile electron acceptor. NAD+ is a required oxidizing cosubstrate for many enzymes. It is reduced to NADH (Cat# N-035) which carries electrons to the electron transport chain for subsequent oxidative phorphorylation and ATP production. NAD+ is capable of donating ADP-ribose moieties to a protein, producing nicotinamide in the process. Sirtuin enzymes use NAD+ as a substrate to deacetylate proteins and direct activity between the nucleus and mitochondria. NAD+ is regenerated by fermentation and by oxidative phosphorylation.
β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a c oenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleot ide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H371 |
| Precautionary statements | P260-P264-P270-P308+P311-P405-P501 |
| Hazard Codes | Xn,F,Xi |
| Risk Statements | 36-68/20/21/22-20/21/22-40-22 |
| Safety Statements | 36-26-36/37-24/25 |
| WGK Germany | 3 |
| RTECS | UU3450000 |
| TSCA | Yes |
| HS Code | 29349990 |
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