Estramustinephosphatesodium , 10mMinWater , 52205-73-9
Synonym(s):
Estra-1,3,5(10)triene-3,17?-diol 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) sodium salt;Estradiol 3-bis(2-chloroethyl)carbamate 17-(dihydrogen phosphate) sodium salt
CAS NO.：52205-73-9
Empirical Formula: C23H33Cl2NNaO6P
Molecular Weight: 544.38
MDL number: MFCD00866320
EINECS: 257-735-7
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB455.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: soluble50mg/mL |
| form | A crystalline solid |
| color | White to off-white |
| Stability: | Hygroscopic, Unstable in Solution |
Description and Uses
Estramustine phosphate is a derivative of estradiol (Item Nos. 20776 | 10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 μM for MAP-1 and MAP-2, respectively. Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells. The metabolites of estramustine phosphate have anti-androgenic effects. Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.
Estramustine phosphate sodium USP (Emcyt) is used to treat Prostatic carcinoma.
