A7693358
Nicardipinehydrochloride , 10mMinDMSO , 54527-84-3
Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methyl(phenylmethyl)amino]ethyl ester hydrochloride;Nicardipine hydrochloride;YC-93
CAS NO.：54527-84-3
Empirical Formula: C26H30ClN3O6
Molecular Weight: 515.99
MDL number: MFCD00057327
EINECS: 259-198-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 176-1780C |
| storage temp. | 2-8°C |
| solubility | DMSO: ~1 mg/mL |
| form | powder |
| color | yellow |
| Merck | 14,6495 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | AIKVCUNQWYTVTO-UHFFFAOYSA-N |
Description and Uses
Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).
Dihydropyridine calcium channel blocker. Antianginal; antihypertensive
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | US7972100 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933399090 |
| Toxicity | LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado) |
