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A7693358

Nicardipinehydrochloride , 10mMinDMSO , 54527-84-3

Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methyl(phenylmethyl)amino]ethyl ester hydrochloride;Nicardipine hydrochloride;YC-93

CAS NO.:54527-84-3

Empirical Formula: C26H30ClN3O6

Molecular Weight: 515.99

MDL number: MFCD00057327

EINECS: 259-198-4

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 176-1780C
storage temp.  2-8°C
solubility  DMSO: ~1 mg/mL
form  powder
color  yellow
Merck  14,6495
Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month.
InChIKey AIKVCUNQWYTVTO-UHFFFAOYSA-N
CAS DataBase Reference 54527-84-3(CAS DataBase Reference)

Description and Uses

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

Dihydropyridine calcium channel blocker. Antianginal; antihypertensive

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331
Precautionary statements  P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
Hazard Codes  T
Risk Statements  23/24/25
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  US7972100
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399090
Toxicity LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)

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