6-Thioguanine , 98% , 154-42-7

Synonym(s):
2-Amino-6-mercaptopurine;2-Amino-6-purinethiol;6-Thioguanine

CAS NO.：154-42-7

Empirical Formula: C5H5N5S

Molecular Weight: 167.19

MDL number: MFCD00233553

EINECS: 205-827-2

PRODUCT Properties

• Melting point: ≥300 °C(lit.)
• Density: 1.483 (estimate)
• refractive index: 1.5605 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water and in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides.
• form: lyophilized powder
• pka: pKa 8.22 (Uncertain)
• Boiling point: 555.4±42.0 °C(Predicted)
• color: Yellow to green
• Water Solubility: soluble
• Merck: 14,9337
• BRN: 157765
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMF may be stored at -20°C for up to 1 month.

Description and Uses

6-Thioguanine (NSC 752, Thioguanine, 2-Amino-6-purinethiol), is an antineoplastic metabolic antagonist that inhibits DNA synthesis by being metabolically converted to 6-thioGMP. This inhibits purine biosynthesis at multiple steps, and may be phosphorylated and incorporated into DNA. In humans, it causes bone marrow depression and gastrointestinal toxicity. Due to safety problems it is currently less used as an antineoplastic agent but has some use as therapy for ulcerative colitis.

6-Thioguanine acts as an antineoplastic and purine antimetabolite. It is also useful as an inhibition of stimulated expression of TNF-related apoptosis-inducing ligand (TRAIL) protein. It is involved in the treatment of acute leukemias and Psoriasis. Further, it is used for the treatment of ulcerative colitis and autoimmune diseases.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310
• Hazard Codes: T,Xi
• Risk Statements: 25-23/24/25
• Safety Statements: 28-36/37/39-45-28A
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UP0740000
• F: 13
• Hazard Note: Irritant
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29335990
• Toxicity: LD50 oral in mouse: 160mg/kg