Isorhamnetin , 10mMinDMSO , 480-19-3

Synonym(s):
3′-Methoxy-3,4′,5,7-tetrahydroxyflavone;3′-Methylquercetin;3,4′,5,7-Tetrahydroxy 3′-methoxyflavone;Isorhamnetol;Quercetin 3′-methyl ether

CAS NO.：480-19-3

Empirical Formula: C16H12O7

Molecular Weight: 316.26

MDL number: MFCD00017310

EINECS: 207-545-5

PRODUCT Properties

• Melting point: 307°C
• Boiling point: 599.4±50.0 °C(Predicted)
• Density: 1.634±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
• pka: 6.31±0.40(Predicted)
• form: Solid
• color: Light yellow to Amber to Dark green
• BRN: 44723
• Stability: Hygroscopic
• InChIKey: IZQSVPBOUDKVDZ-UHFFFAOYSA-N
• LogP: 1.760 (est)

Description and Uses

Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin . It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 μM). Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 μM), which has an important role in the excretion of xenobiotics at the kidney and liver. It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H351
• Precautionary statements: P281-P280
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-40
• Safety Statements: 22-36-26-36/37
• WGK Germany: 3
• RTECS: LK9275450
• HS Code: 29329990