Mitotane , 10mMinDMSO , 53-19-0

Synonym(s):
Mitotane;o,p′-DDD;(2,4′-Dichlorodiphenyl)dichloroethane;o,p′-DDD;1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane

CAS NO.：53-19-0

Empirical Formula: C14H10Cl4

Molecular Weight: 320.04

MDL number: MFCD00000850

EINECS: 200-166-6

PRODUCT Properties

• Melting point: 77-78 °C(lit.)
• Boiling point: 405.59°C (rough estimate)
• Density: 1.3118 (rough estimate)
• refractive index: 1.6000 (estimate)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO: soluble20mg/mL, clear
• form: powder
• color: white to beige
• Water Solubility: <0.1 g/100 mL at 24 ºC
• Merck: 13,6237 / 13,6237
• BRN: 2056007
• InChI: InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
• InChIKey: JWBOIMRXGHLCPP-UHFFFAOYSA-N
• SMILES: C1(Cl)=CC=CC=C1C(C1=CC=C(Cl)C=C1)C(Cl)Cl
• CAS DataBase Reference: 53-19-0(CAS DataBase Reference)
• NIST Chemistry Reference: Mitotane(53-19-0)
• EPA Substance Registry System: o,p'-DDD (53-19-0)

Description and Uses

Mitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells. It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells. Mitotane has anti-neoplastic actions, alone or in combination with other compounds, and suppresses cortisol synthesis, although it also has significant toxicity in the gastrointestinal tract and nervous system. It is effective against adrenocortical carcinoma and Cushing’s Syndrome in clinical trials.

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Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H351
• Precautionary statements: P280
• Hazard Codes: Xn
• Risk Statements: 40
• Safety Statements: 36/37
• RIDADR: 3249
• WGK Germany: 3
• RTECS: KH7880000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2903990002
• Hazardous Substances Data: 53-19-0(Hazardous Substances Data)