L-Thyroxine , 98% , 51-48-9
Synonym(s):
L -Thyroxine;3,3′,5,5″-Tetraiodo-L -thyronine;3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L -alanine;T4
CAS NO.：51-48-9
Empirical Formula: C15H11I4NO4
Molecular Weight: 776.87
MDL number: MFCD00002596
EINECS: 200-101-1
| Pack Size | Price | Stock | Quantity |
| 1G | RMB84.00 | In Stock |
|
| 5G | RMB279.20 | In Stock |
|
| 25G | RMB1116.00 | In Stock |
|
| 100G | RMB3173.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 235 °C |
| alpha | -5 º (1N NaOH:EtOH 1:2) |
| Density | 2.4440 (estimate) |
| Flash point: | 9℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Dissolves in 4M ammonium hydroxide in Methanol at 50mg/ml |
| pka | 2.2(at 25℃) |
| Boiling point: | 576.3±50.0 °C(Predicted) |
| form | Powder |
| color | White to Pale Brown |
| optical activity | -4.5 to -5.7 [1 mol dm-3 NaOH-ethanol (1:2)] +15 [1 mol dm-3 HCl-95% ethanol (1:2)] |
| Water Solubility | insoluble |
| Sensitive | Light Sensitive |
| Merck | 9491 |
| BRN | 2228515 |
| InChIKey | XUIIKFGFIJCVMT-LBPRGKRZSA-N |
| CAS DataBase Reference | 51-48-9(CAS DataBase Reference) |
| EPA Substance Registry System | L-Thyroxine (51-48-9) |
Description and Uses
L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.
Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
Safety
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310+P330-P302+P352+P312-P370+P378 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 40-39/23/24/25-23/24/25-11 |
| Safety Statements | 22-24/25-36-45-36/37-16 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | YP2833500 |
| F | 8-10 |
| TSCA | Yes |
| HazardClass | IRRITANT |
| HS Code | 29379000 |
| Hazardous Substances Data | 51-48-9(Hazardous Substances Data) |
| Toxicity | TDLo oral in child: 328ug/kg |
