Ibudilast , 10mMinDMSO , 50847-11-5

Synonym(s):
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone;3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine;KC-404

CAS NO.：50847-11-5

Empirical Formula: C14H18N2O

Molecular Weight: 230.31

MDL number: MFCD00864808

EINECS: 637-150-7

PRODUCT Properties

• Melting point: 53-54°C
• Boiling point: 175°C/7.5mmHg(lit.)
• Density: 1.09
• refractive index: 1.5500 (estimate)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO: 28 mg/mL, soluble
• form: solid
• pka: 1.22±0.30(Predicted)
• color: white
• Merck: 14,4879
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChI: InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
• InChIKey: ZJVFLBOZORBYFE-UHFFFAOYSA-N
• SMILES: C(C1=C2N(N=C1C(C)C)C=CC=C2)(=O)C(C)C

Description and Uses

Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.

a phosphodiesterase inhibitor with anti-inflammatory activity

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: UR0711200
• HS Code: 2933.99.8290
• Toxicity: LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)