Thimerosal , 97% , 54-64-8
Synonym(s):
Thimerosal;([o-Carboxyphenyl]thio)ethylmercury sodium salt;2-(Ethylmercuriomercapto)benzoic acid sodium salt;Ethylmercurithiosalicylic acid sodium salt;Mercury-([o-carboxyphenyl]thio)ethyl sodium salt
CAS NO.：54-64-8
Empirical Formula: C9H9HgNaO2S
Molecular Weight: 404.81
MDL number: MFCD00013062
EINECS: 200-210-4
PRODUCT Properties
| Melting point: | 234-237 °C (dec.)(lit.) |
| Flash point: | 250 °C |
| storage temp. | Store at RT. |
| solubility | methanol: 0.1 g/mL, ≤ 10 TE CF |
| form | Powder |
| color | white to off-white |
| PH | 6.0～8.0 (10g/L, 25℃) |
| Water Solubility | 1 G/ML (20 ºC) |
| Merck | 13,9389 |
| BRN | 8169555 |
| Stability: | Stable. May degrade in sunlight. Incompatible with strong acids, strong bases, strong oxidizing agents, iodine, heavy metal salts. |
| InChI | InChI=1S/C7H6O2S.C2H4.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H,2H3;;/q;-1;2*+1/p-1 |
| InChIKey | RTKIYNMVFMVABJ-UHFFFAOYSA-L |
| SMILES | O=C1[O-][Hg+2]([CH-]C)[SH-]C2=CC=CC=C12.[Na+] |
Description and Uses
Since the 1930s, thimerosal (sodium ethylmercury thiosalicylate) has been used in the manufacture of vaccines to prevent fungal or bacterial contamination of multidose preparations. The single-dose vaccines are much more expensive and thus the use of the preservative significantly reduces the cost of vaccination. There is controversy as to whether the use of thimerosal in vaccines is an etiological factor in autism and other neurodevelopmental disorders such as attention deficit hyperactivity disorder. It has been estimated that children exposed to mercury-containing vaccines could be exposed to levels of mercury far beyond those considered safe by the US Food and DrugAdministration (FDA) standards. Therefore, in 1999, theUS Public Health Service agencies urged vaccine manufacturers to stop or limit the use of the preservative in vaccine formulations. Today, the vaccines on the US Recommended Childhood and Adolescent Immunization Schedule are thimerosal-free although some formulations of the influenza vaccine still contain the mercury-containing preservative. The Centers for DiseaseControl and Prevention (CDC) has discounted an association between exposure to this organic ethylmercury compound and autism. This is based on studies showing that the risk of autism is not increased in children treated with vaccines containing the preservative compared with children who were vaccinated with thimerosal-free formulations. Furthermore, in Denmark, the use of the preservative was discontinued after 1992. After removal of thimerosal, there was a continued rise in new cases of autism.
nootropic Anti-Alzheimer’s drug main ingredient of Neupramir derived from Piracetam but 8-30 times more potent
Safety
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H373-H410 |
| Precautionary statements | P262-P273-P280-P302+P352+P310-P304+P340+P310-P314 |
| Hazard Codes | T+,N,T |
| Risk Statements | 26/27/28-33-50/53 |
| Safety Statements | 13-28-36-45-60-61-28A |
| RIDADR | UN 2025 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | OV8400000 |
| F | 8 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29310095 |
| Toxicity | LD50 s.c. in rats: 98 mg/kg (Mason) |
