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A7676358

Neratinib(HKI-272) , 2mMinDMSO , 698387-09-6

CAS NO.:698387-09-6

Empirical Formula: C30H29ClN6O3

Molecular Weight: 557.04

MDL number: MFCD09752958

EINECS: 811-237-1

Pack Size Price Stock Quantity
1ml RMB239.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 185-187°C
Boiling point: 757.0±60.0 °C(Predicted)
Density  1.33
storage temp.  Refrigerator
solubility  Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
form  Off-white solid.
pka 12.37±0.43(Predicted)
color  Pale Yellow to Yellow

Description and Uses

The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal growth factor receptor complexes that are known to have central roles in cell proliferation and cancer. Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC50 = 59 nM). It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib . Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively.

Safety

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H314-H290
Precautionary statements  P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
HS Code  29334900

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