Neratinib(HKI-272) , 2mMinDMSO , 698387-09-6
CAS NO.：698387-09-6
Empirical Formula: C30H29ClN6O3
Molecular Weight: 557.04
MDL number: MFCD09752958
EINECS: 811-237-1
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB239.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 185-187°C |
| Boiling point: | 757.0±60.0 °C(Predicted) |
| Density | 1.33 |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated) |
| form | Off-white solid. |
| pka | 12.37±0.43(Predicted) |
| color | Pale Yellow to Yellow |
Description and Uses
The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal growth factor receptor complexes that are known to have central roles in cell proliferation and cancer. Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC50 = 59 nM). It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib . Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.
Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively.
Safety
| Symbol(GHS) |  GHS05 |
| Signal word | Danger |
| Hazard statements | H314-H290 |
| Precautionary statements | P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405 |
| HS Code | 29334900 |
