Home Categories Chemical Reagents Thioglycolic acid
A7675812

Thioglycolic acid , ≥98%(T) , 68-11-1

Synonym(s):
Mercaptoacetic acid;Mercaptoacetic acid, 2-Mercaptoethanoic acid;Thioglycolic acid

CAS NO.:68-11-1

Empirical Formula: C2H4O2S

Molecular Weight: 92.12

MDL number: MFCD00004876

EINECS: 200-677-4

Update time: 2022-07-08

PRODUCT Properties

Melting point: −16 °C(lit.)
Boiling point: 96 °C5 mm Hg(lit.)
Density  1.326 g/mL at 20 °C(lit.)
vapor density  3.2 (vs air)
vapor pressure  0.4 mm Hg ( 25 °C)
refractive index  n20/D 1.505(lit.)
Flash point: 126 °C
storage temp.  Store at +2°C to +8°C.
solubility  Chloroform (Sparingly), Methanol (Sparingly)
form  Liquid
pka 3.68(at 25℃)
color  clear clear, colorless
PH 1 (H2O, 20℃)
Odor strong unpleasant odor
Water Solubility  soluble
Sensitive  Air Sensitive
Merck  14,9336
BRN  506166
Exposure limits TLV-TWA 1 ppm (~3.8 mg/m3) (ACGIH).
Stability: Air Sensitive
InChIKey CWERGRDVMFNCDR-UHFFFAOYSA-N
LogP 0.090

Description and Uses

Thio glycolic acid (TGA) is the organic compound HSCH2CO2H . It contains both a thiol (mercaptan) and a carboxylic acid. It is a clear liquid with a strong unpleasant odor. It is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
TGA was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. TGA is the precursor to ammonium thioglycolate that is used for permanents. TGA and its derivatives break the disulfide bonds in the cortex of hair. One reforms these broken bonds in giving hair a "perm." Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing. It is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
TGA is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
TGA, usually as its dianion, forms complexes with metal ions. Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.

Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents. Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.

Safety

Symbol(GHS) 
GHS05,GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H314-H317
Precautionary statements  P261-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T,T+
Risk Statements  23/24/25-34-26-24/25
Safety Statements  25-27-28-45-36/37-28C-23
RIDADR  UN 1940 8/PG 2
OEB B
OEL TWA: 1 ppm (4 mg/m3) [skin]
WGK Germany  1
RTECS  AI5950000
9-13-23
Autoignition Temperature 662 °F
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29309070
Toxicity LD50 orally in rats: 0.15 ml/kg (Deichmann, Mergard)

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