PiromidicAcid , 10mMinDMSO , 19562-30-2
CAS NO.：19562-30-2
Empirical Formula: C14H16N4O3
Molecular Weight: 288.3
MDL number: MFCD00058574
EINECS: 243-161-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 314-316° |
| Boiling point: | 430.54°C (rough estimate) |
| Density | 1.1895 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 0-6°C |
| solubility | Chloroform (Slightly, Heated, Sonicated), Ethanol (Slightly, Heated) |
| form | Solid |
| pka | 4.14±0.20(Predicted) |
| color | Crystals from EtOH/CHCl3 |
Description and Uses
Piromidic acid is a quinolone antibiotic that is active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 μg/ml, respectively). It inhibits growth of nalidixic acid-sensitive strains of E. coli in an in vitro model of bacterial cystitis when used at concentrations of 10 and 50 mg/L. Piromidic acid also has antimalarial properties and is active against chloroquine-sensitive and -resistant strains of P. falciparum in vitro (IC50s = 41.4 and 14.4 μg/ml, respectively) as well as against hepatic stages of P. yoelii yoelii (IC50 = 21.6 μg/ml).
Antibacterial;Topoisomerase II inhibitor
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 287, 268, 177, 158 i.v.; all >4000 orally, s.c. and i.p. (Shimizu) |
