PRODUCT Properties
| Melting point: | >175°C (dec.) |
| Boiling point: | 826.2±65.0 °C(Predicted) |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.54±0.50(Predicted) |
| form | Off-white to yellow/brown crystalline solid. |
| color | Off-White to Pale Yellow |
| Stability: | Hygroscopic |
| InChIKey | KRZBCHWVBQOTNZ-PSEXTPKNSA-N |
Description and Uses
3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants. It has antioxidant, anti-inflammatory, and antiviral biological activities. 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM). It inhibits HIV-1 integrase 3''-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml). In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).
Isochlorogenic Acid A is a phenolic compound shown to provide protection against oxidative stress cells. DNA protective agent.
Safety
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | GU8403966 |
| HS Code | 29189900 |
