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A7672658

MexiletineHCl , 10mMinDMSO , 5370-01-4

Synonym(s):
1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride;1-(2,6-Xylyloxy)-2-aminopropane hydrochloride;Mexiletine hydrochloride

CAS NO.:5370-01-4

Empirical Formula: C11H18ClNO

Molecular Weight: 215.72

MDL number: MFCD00216024

EINECS: 226-362-1

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 200-203°C
Density  1.12 g/cm3
storage temp.  2-8°C
solubility  ethanol: 50 mg/mL
form  powder
pka 9.0(at 25℃)
color  white
λmax 272nm(MeOH)(lit.)
Merck  14,6169
Stability: Hygroscopic

Description and Uses

Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 μg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.

antipsychotic

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38-22
Safety Statements  36-26
WGK Germany  3
RTECS  KR9300000
HS Code  2922190900
Toxicity LD50 in male, female rats, mice, rabbits (mg/kg): 350, 400, 310, 400, 180, 160 orally; in male, female rats, mice (mg/kg): 27, 30, 43, 50 i.v. (Kast)

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