A7672658
MexiletineHCl , 10mMinDMSO , 5370-01-4
Synonym(s):
1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride;1-(2,6-Xylyloxy)-2-aminopropane hydrochloride;Mexiletine hydrochloride
CAS NO.：5370-01-4
Empirical Formula: C11H18ClNO
Molecular Weight: 215.72
MDL number: MFCD00216024
EINECS: 226-362-1
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 200-203°C |
| Density | 1.12 g/cm3 |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mg/mL |
| form | powder |
| pka | 9.0(at 25℃) |
| color | white |
| λmax | 272nm(MeOH)(lit.) |
| Merck | 14,6169 |
| Stability: | Hygroscopic |
Description and Uses
Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 μg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.
antipsychotic
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38-22 |
| Safety Statements | 36-26 |
| WGK Germany | 3 |
| RTECS | KR9300000 |
| HS Code | 2922190900 |
| Toxicity | LD50 in male, female rats, mice, rabbits (mg/kg): 350, 400, 310, 400, 180, 160 orally; in male, female rats, mice (mg/kg): 27, 30, 43, 50 i.v. (Kast) |
